欧云生

欧云生

医学博士，教授，博士生导师。重庆医科大学附属第一医院骨科（脊柱外科）第三组医疗组长。

脊柱专科门诊时间：星期一下午、星期四全天；

临床专长：从事临床一线工作25余年，临床工作认真细致，现为重庆市脊柱外科中心主要成员，我院脊柱外科手术操作骨干医生，年开展脊柱外科手术600~800台。对脊柱外科5大病种（1、脊柱退行性疾病：如颈椎病、腰椎间盘突出、椎管狭窄、椎体滑脱等；2、脊柱、脊髓外伤：如齿状突骨折、椎体爆裂性骨折、脊髓血肿等；3、脊柱、脊髓肿瘤：如椎管内占位、脊柱转移性肿瘤、骶骨肿瘤等；4、脊柱畸形：如青少年特发性脊柱侧弯、退变性脊柱侧弯、先天斜颈等；5：脊柱炎症：脊柱感染、结核等。）的诊治积累了丰富的临床经验。

近年来，该团队以“快速康复”为治疗理念，率先在院内开展多项脊柱微创技术，大大减轻了患者的痛苦，同时缩短了住院时间和总体费用。开展的斜前方椎间融合术(OLIF)将传统的手术切口缩小到2.5cm； 微通道下椎间孔入路椎间融合术(MIS-TLIF)患者于术后第二日即可下床活动；对于偏年轻的患者采用Dynesys动态稳定技术，既解除了神经压迫又保留腰椎的运动功能；对脊柱结核患者主张在严格抗痨治疗的基础上，强调“颗粒状植骨”和“置管冲洗引流”，显著降低了结核的复发，提高了总体治愈率；对部分胸腰椎骨折患者采用经皮螺钉固定技术，无需手术切开，大大减少了卧床时间；即使是开放手术，在非减压侧多采用肌间隙入路植钉，最大程度减少对腰背肌的剥离。该团队开展的多项脊柱外科医疗技术达国内、国际先进水平，曾多次举办学习班、继教班，获业内人士好评。

学术任职：担任中华医学会骨科分会第十一届委员会骨科康复学组委员；中国残疾人康复协会肢体残疾康复专业委员会脊柱微创学组常委；中华医学会医学工程学分会数字骨科学组脊柱与骨病工作委员会委员；中国医药教育协会骨科专业委员会脊柱分会委员；重庆市医学会骨科专业委员会第六届委员会脊柱学组委员；重庆市医师协会骨科医师分会第一届委员会脊柱外科学组委员等；《创伤外科杂志》编委；《重庆医科大学学报》审稿人；《Spine》、《International Journal of Oncology》、《Oncology Reports》, 《Oncology Letter》等期刊的审稿人。

主研方向：近年来以骨肿瘤、生物材料、脊柱微创技术作为研究方向，取得一定的研究成果。在研课题有：《以PERK为靶点抑制内质网应激性自噬在逆转骨肉瘤光动力疗法耐受中的作用和机制》、《自组装肽-磷酸钙-纳米羟基磷灰石复合生物材料对骨修复的影响及机制研究》；

主要成果：主持国家自然科学基金、重庆市科委、重庆市卫计委等科研课题11项，参与科研课题10余项；以第一及通讯作者在国内外核心期刊发表科研论文84篇，其中SCI 13篇（总IF分值33.993分）；申请专利1项，获重庆市科技进步二等奖1项、重庆市卫生局科技成果三等奖1项；参编专著《外科症状鉴别诊断》,《老年人运动系统疾病》 ；培养校级优秀毕业生数名并获学生好评教师称号；多次于全国及地区大型骨科学术会议上发言和主持。

典型病例：

主要文献：

1. Zhu Yong, Wu Peng, Luo Wei, Zhao Zenghui, Ou Yunsheng (Corresponding author). Single-Stage Posterior Instrumentation and Unilateral Transpedicular Debridement for the Treatment of Thoracolumbar Tuberculosis: Three Years of Follow-Up.World Neurosurg. 2018 Sep 24. pii: S1878-8750(18)32131-4. doi: 10.1016/j.wneu.2018.09.085. (Original Article). Impact Factor: 1.924 (2017).

2. Chen Yanyang, Ou Yunsheng (Corresponding author), Tao Yong, Liu Huzhe, Yin Hang, Zhong Shenxi, Yu Haoyang, Zhao Zenghui, He Bin.Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells.. Oncology Reports. 2018 Oct; 40(4):2260-2268. ( doi: 10.3892/or.2018.6619). Impact Factor: 2.976 (2017).

3. Zhao Zenghui, Guo Liang, Zhu Yong, Luo Wei, Ou Yunsheng (Corresponding author), Quan Zhengxue, Jiang Dianming. Clinical Use of a New Nano-Hydroxyapatite/Polyamide66 Composite Artificial Lamina in Spinal Decompression Surgery: More Than 4 Years' Follow-Up.Medical Science Monitor. 2018 Aug 11;24:5573-5579.( doi: 10.12659/MSM.907958). (Clinical Research) Impact Factor: 1.894 (2017).

4. He Bin, Zhao Jinqiu, Ou Yunsheng(Corresponding author), Jiang Dianming. Biofunctionalized peptide nanofiber-based composite scaffolds for bone regeneration. Mater Sci Eng C Mater Biol Appl. 2018，90:728-738 . (doi: 10.1016/j.msec.2018.04.063). Impact Factor: 5.08 (2017).

5. Tao Yong, Ou YunSheng (Corresponding author), Yin Hang, Chen Yanyang, Zhong Shenxi, Gao Yongjian, Zhao Zenghui, He Bin, Huang Qiu, Deng Qianxing. Establishment and characterization of human osteosarcoma cells resistant to pyropheophorbide-α methyl ester-mediated photodynamic therapy. International Journal Of Oncology. 2017, 51: 1427-1438. DOI: 10.3892/ijo.2017.4136. Impact Factor: 3.333 (2017).

6. Shi Houyin, Ou Yunsheng, Jiang Dianming, Quan Zhengxue, Zhao Zenghui, Zhu Yong. Tranexamic acid reduces perioperative blood loss of posterior lumbar surgery for stenosis or spondylolisthesis: A randomized trail. Medicine ( Baltimore ) 2017 Jan; 96(1): e5718. doi: 10.1097/MD.0000000000005718. Impact Factor: (2017).

7. Gao Yongjian, Ou Yunsheng(Corresponding author), Deng Qianxing, He Bin, Du Xing, Li Jianxiao. Comparison between titanium mesh and autogenous iliac bone graft to restore vertebral height through posterior approach for the treatment of thoracic and lumbar spinal tuberculosis.PLoS ONE. 2017; 12(4): e0175567. (Research Article). http://doi.org/10.1371/journal.pone.0175567. Impact Factor: 2.766 (2017).

8. Li KT , Chen Q , Wang DW , Duan QQ , Tian S , He JW , Ou YS(Corresponding author), Bai DQ(Corresponding author). Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE-PDT in MG63 cells. Cancer Medicine. 2016 Nov; 5(11): 3186-3193. doi: 10.1002/cam4.895. Impact Factor: 3.362 (2016).

9. He B, Ou Y, Chen S, Zhao W, Zhou A, Zhao J, Li H, Jiang D, Zhu Y. Designer bFGF-incorporated d-form self-assembly peptide nanofiber scaffolds to promote bone repair. Mater Sci Eng C Mater Biol Appl. 2017 May 1; 74: 451-458. (doi: 10.1016/j.msec.2016.12.042). Impact Factor: 4.164 (2016).

10. He Bin, Ou Yunsheng, Zhou Ao, Chen Shuo, Zhao Weikang, Zhao Jinqiu, Li Hong, Zhu Yong, Zhao Zenghui, Jiang Dianming. Functionalized D-form self-assembling peptide hydrogels for bone regeneration. Drug Design, Development and Therapy. 2016, 10 : 1379-1388. (DOI: 10.2147/DDDT.S97530). Impact Factor: (2016).

11. Huang Qiu, Ou Yun-Sheng (Corresponding author), Tao Yong, Yin Hang, Tu Ping-Hua. Apoptosis and autophagy induced by pyropheophorbide-α methyl ester - mediated photodynamic therapy in human osteosarcoma MG-63 cells. Apoptosis. 2016, 21: 749-760. DOI: 10.1007/s10495-016-1243-4. Impact Factor: 3.833 (2016).

12. Deng Qian-xing, Ou Yun-sheng (Corresponding author), Zhu Yong, Zhao Zeng-hui, Liu Bo, Huang Qiu, Du Xing, Jiang Dian-ming. Clinical outcomes of two types of cages used in transforaminal lumbar interbody fusion for the treatment of degenerative lumbar diseases: n-HA/PA66 cages versus PEEK cages. Journal of Materials Science-Materials in Medicine. 2016, 27:102. (DOI: 10.1007/s10856-016-5712-7). Impact Factor: 2.325(2016).

13. Tu Pinghua, Huang Qiu（共同第一作者）, Ou Yunsheng (Corresponding author), Du Xing, Li Kaiting, Tao Yong, Yin Hang. Aloe-Emodin-Mediated Photodynamic Therapy Induces Autophagy and Apoptosis in Human Osteosarcoma Cell Line MG-63 through ROS-JNK signal pathway. Oncology Reports, 35: 3209-3215, 2016. DOI: 10.3892/or.2016.4703. SCI (Print ISSN: 1021-335X. Online ISSN: 1791-2431.Impact Factor: 2.662(2016).

14. Li S, Ou Y (Corresponding author), Liu B, Zhu Y, Quan Z, Jiang D. Comparison of osteotomy versus non-osteotomy approach for congenital scoliosis: a retrospective study of three surgical techniques. ANZ J Surg. 2015 Apr; 85(4): 249-54. doi: 10.1111/ans.12886（Original Article. SCI. IF(2015):1.158, ISSN: 1445-1433）

15. Li KT, Zhang J, Duan QQ, Bi Y, Bai DQ, Ou YS(Corresponding authors). Apoptosis triggered by pyropheophorbide-α methyl ester-mediated photodynamic therapy in a giant cell tumor in bone. Laser Physics. 24(2014), 066002(7pp). Doi:10.1088/1054-660X/24/6/066002.（Original Article. SCI. IF(2014):1.032, ISSN: 1054-660X）

16. Nie H,Hao J,Peng C,Ou Y,Quan Z,An H. Clinical outcomes of discectomy in octogenarian patients with lumbar disc herniation．Journal of spinal disorders & techniques. 2013, 26(2): 74-8. Impact Factor: (2013).

17. Liu B, Jiang D, Ou Y, Hu Z, Jiang J, Lei X.An anti-inflammatory role of A20 zinc finger protein during trauma combined with endotoxin challenge.J Surg Res. 2013 Dec;185(2):717-25. Impact Factor: (2013).

18. Ou YS, Tan C, An H(通讯作者), Jiang DM, Quan ZX, Tang K, Luo XJ. The effects of NSAIDs on types I, II, and III collagen metabolism in a rat osteoarthritis model. Rheumatol Int. 2012 Aug; 32(8):2401-2405.（Original Article. SCI. IF(2012):2.214, ISSN: 0172-8172）

19. Ou Y, Tan C, An H(通讯作者), Jiang D, Quan Z, Tang K, Luo X. Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte.Med Sci Monit. 2012 Jun 1;18(6):BR247-252.（Basic Research. SCI. IF(2012): 1.358 , ISSN：1234-1010.

20. Zhao Z,Jiang D,Ou Y,Tang K,Luo X,Quan Z. A hollow cylindrical nano-hydroxyapatite/polyamide composite strut for cervical reconstruction after cervical corpectomy.J Clin Neurosci.2012 Apr;19(4):536-40.Impact Factor: (2012).