李琦 教授
重庆医科大学附属第一医院，神经内科主任医师，教授，博士生导师。现任中国卒中学会第二届青年理事会常务理事、中国卒中学会医疗质量管理与促进分会第二届委员会委员、中华医学会神经病学分会第八届委员会神经影像协作组委员、中华全国青年联合会第十三届委员会委员。
入选国家高层次人才特殊支持计划（万人计划）青年拔尖人才、重庆市杰青、重庆市青年拔尖人才、中国科协青年人才托举工程等；在Lancet、Annals of Neurology、Neurology、Radiology、Stroke、JNNP等杂志发表SCI论文100余篇；主持国家重点研发计划项目课题、国自然面上项目等科研项目10余项，累计经费971万元；获得重庆市科技进步二等奖1项（第一完成人），省部级科技进步一等奖4项，授权专利5项；获得美国神经病学会国际学者奖、中国杰出神经内科医师-青年医师奖等荣誉。
研究方向
长期致力于脑血管疾病及神经影像学研究，提出并命名了混合征、黑洞征、李琦岛征三个平扫CT征象预测脑出血早期血肿扩大，被哈佛大学等学者验证并广泛应用于临床，写入美国医学院教学资料；在国际上首次提出并命名罕见脑血管疾病“椎动脉压迫综合征”（Vertebral artery compression syndrome）；提出脑出血超早期治疗时间窗概念，并证明超早期治疗能够改善患者预后。3篇文章被F1000收录和推荐，研究成果写入10部国内外指南并成为脑出血CT影像学国际标准。
代表性论文
1. Li Q#, Warren AD, Qureshi AI, Morotti A, Falcone GJ, Sheth KN, Shoamanesh A, Dowlatshahi D, Viswanathan A, Goldstein JN. Ultra-Early Blood Pressure Reduction Attenuates Hematoma Growth and Improves Outcome in Intracerebral Hemorrhage. Ann Neurol. 2020 May 26, 88(2):388-395.
2. Li Q#, Zanon Zotin MC, Warren AD, Ma Y, Gurol E, Goldstein JN, Greenberg SM, Charidimou A, Raposo N, Viswanathan A. CT-Visible Convexity Subarachnoid Hemorrhage is Associated With Cortical Superficial Siderosis and Predicts Recurrent ICH. Neurology. 2021 Feb 16; 96(7):e986-e994.
3. Li Q#, Goldstein JN. Neurological Deterioration in Intracerebral Hemorrhage: Can We Predict It, and What Would We Do If We Could? J Am Heart Assoc. 2022 Aug 2;11(15):e026760.
4. Li XH, Yang WS, Shen YQ, Liu F, Xiong X, Wu QY, Xiao ZS, Yang X, Dang R, Manaenko A, Xie P, Li Q*. Analysis of Age-Dependent Transcriptomic Changes in Response to Intracerebral Hemorrhage in Mice. Front Mol Neurosci. 2022 May 23;15:908683.
5. Wang ZJ, Zhao R, Hu X, Yang WS, Deng L, Lv XN, Li ZQ, Cheng J, Pu MJ, Tang ZP, Wu GF, Zhao LB, Xie P, Li Q*. Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage. Front Neurosci. 2022 May 12;16:888198.
6. Shen YQ, Yang WS, Xiong X, Li XH, Xiao ZS, Yu JL, Liu FY, Gui SW, Xie XF, Lv FJ, Zhao LB, Hu LB, Manaenko A, Xie P*, Li Q*. Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage, Oxidative Medicine and Cellular Longevity, 2021, 2021: 2510847.
7. Lv XN, Li ZQ, Deng L, Yang WS, Li YL, Huang YJ, Shen YQ, Xie XF, Li XH, Wang ZJ, Zhang ZW, Lv FJ, Luo JB, Sun SJ, Xie P, Li Q*. Early Perihematomal Edema Expansion: Definition, Significance, and Association with Outcomes after Intracerebral Hemorrhage. Oxid Med Cell Longev. 2021 Sep 12;2021:6249509.
8. Li Q#, Wang ZJ, Viswanathan A. Intracerebral hemorrhage and small vessel disease. Chin Med J (Engl). 2021 Sep 9;134(19):2287-2289.
9. Akram MJ, Zhao R, Shen X, Yang WS, Deng L, Li ZQ, Hu X, Zhao LB*, Xie P*, Li Q*. Surgical vs. Conservative Management for Lobar Intracerebral Hemorrhage, a Meta-Analysis of Randomized Controlled Trials. Front Neurol. 2022 Jan 20;12:742959.
10. Li YL, Zhao R, Zheng YN, Wei M, Li ZQ, Hu X, Li Q*, Lv FJ*. 3D island sign on computed tomography predicts early perihematomal edema expansion and poor outcome in patients with intracerebral hemorrhage. Clin Neurol Neurosurg. 2022 Sep 15;222:107443.
11. Yang WS, Shen YQ, Yang X, Li XH, Xu SH, Zhao LB, Li R, Xiong X, Bai SJ, Wu QY, Manaenko A, Li Q*, Xie P*. MicroRNA Transcriptomics Analysis Identifies Dysregulated Hedgehog Signaling Pathway in a Mouse Model of Acute Intracerebral Hemorrhage Exposed to Hyperglycemia. J Stroke Cerebrovasc Dis. 2022 Mar;31(3):106281.
12. Li YL, Lv XN, Wei X, Yang WS, Li R, Deng L, Wei M, Li Q*, Lv FJ*. Relationship Between Non-contrast Computed Tomography Imaging Markers and Perihemorrhagic Edema Growth in Intracerebral Hemorrhage. Neurocrit Care. 2021 May 3.
13. Yang WS, Shen YQ, Wei X, Zhao LB, Liu QJ, Xie XF, Zhang ZW, Deng L, Lv XN, Zhang SQ, Li XH, Li Q*, Xie P*. New Prediction Models of Functional Outcome in Acute Intracerebral Hemorrhage: The dICH Score and uICH Score. Front Neurol. 2021, 12 (536).
14. Lv XN, Deng L, Yang WS, Wei X*, Li Q*. Computed Tomography Imaging Predictors of Intracerebral Hemorrhage Expansion. Curr Neurol Neurosci Rep. 2021 Mar 12;21(5):22.
15. Li Q#, Deng L, Huang C, Zhang WY, Zou N, Cao D, Wei X, Qin XY. A Novel Scale for Assessment of Stroke Severity at Symptom Onset: Correlation With Neurological Deterioration and Outcome. Front Neurol. 2021 Jan 22;11:602839.
16. Yang WS, Zhang SQ, Shen YQ, Wei X, Zhao LB, Xie XF, Deng L, Li XH, Lv XN, Lv FJ, Dowlatshahi D, Li Q*, Xie P*. Noncontrast Computed Tomography Markers as Predictors of Revised Hematoma Expansion in Acute Intracerebral Hemorrhage. J Am Heart Assoc. 2021 Feb 2.
17. Ye F, Li J, Wang T, Lan K, Li H, Yin H, Guo T, Zhang X, Yang T, Liang J, Wu X, Li Q*, Sheng W*. Efficacy and Safety of Antiplatelet Agents for Adult Patients With Ischemic Moyamoya Disease. Front Neurol. 2021 Jan 15.
18. Li Y, Ren S, Wang L, Mao Y, Wu G*, Li Q*, Tang Z*. Is the CT Blend Sign Composed of Two Parts of Blood with Different Age? Neurocrit Care. 2021 Jan 6.
19. Deng L, Zhang YD*, Ji JW, Yang WS, Wei X, Shen YQ, Li R, Zhang SQ, Lv XN, Li XH, Tang ZP, Wu GF, Zhao LB, Xie P, Li Q*. Hematoma Ventricle Distance on Computed Tomography Predicts Poor Outcome in Intracerebral Hemorrhage. Front Neurosci. 2020 Nov 19;14:589050.
20. Yang WS, Shen YQ, Zhang XD, Zhao LB, Wei X, Xiong X, Xie XF, Li R, Deng L, 20. Li XH, Lv XN, Lv FJ, Li Q*, Xie P*. Hydrocephalus Growth: Definition, Prevalence, Association with Poor Outcome in Acute Intracerebral Hemorrhage. Neurocrit Care. 2020 Nov 10.
