郭玉洁 博士后

研究方向

围绕博尔纳病病毒，研究病毒的分子流行病学特征，致病机理；探讨病毒在恶性肿瘤中的作用及机制；利用现代分子生物学的手段构建完整的病毒载体，为恶性肿瘤的有效治疗拓开新的治疗策略。作为主要完成人之一，相关研究成果获得贵州省科学技术进步奖二等奖。

代表性论文

1. Guo Y#, Xu X#, Tang T#, Sun L#, Zhang X, Shen X, Li D, Wang L, Zhao L, Xie P. miR-505 inhibits replication of Borna disease virus 1 via inhibition of HMGB1-mediated autophagy[J]. Journal of General Virology, 2022, 103(1).

2. Bode L#, Guo Y#, Xie P. Molecular epidemiology of human Borna disease virus 1 infection revisited[J]. Emerging Microbes & Infections, 2022: 1-36.

3. Tang T#, Guo Y#, Xu X#, Zhao L#, Shen X, Sun L, Xie P. BoDV-1 infection induces neuroinflammation by activating the TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats[J]. Journal of Medical Virology, 2021, 93(11): 6163–6171.

4. Guo Y#, He P#, Sun L#, Zhang X, Xu X, Tang T, Zhou W, Li Q, Zou D, Liv Bode, Xie P. Full‐length Genomic Sequencing and Characterization of Borna Disease Virus 1 Isolates – lessons on epidemiology. Journal of Medical Virology, 2020: jmv.25951.

5. Shen X#, Xu X#, Guo Y#, Hongli Yang, Juan He and Peng Xie.Borna disease virus 1 impairs DNA double-strand break repair through the ATR/Chk1 signalling pathway, resulting in learning and memory impairment in rats[J].Journal of General Virology, 2023, 103(12).

6. Sun L#, Guo Y#, He P#, Xu X, Zhang X, Wang H, Tang T, Zhou W, Xu P, Xie P. Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus. Genes & Diseases, 2019, 6(2): 147–158.                                                

7. Zhang X#, Guo Y#, Xu X, Tang T, Sun L, Wang H, Zhou W, Fang L, Li Q, Xie P. miR-146a promotes Borna disease virus 1 replication through IRAK1/TRAF6/NF-κB signaling pathway. Virus Research, 2019, 271: 197671.

8. Mao, Q#, Zhang L#, Guo Y#, Sun lu, Xie, P*. Identification of suitable reference genes for analysis of miRNAs in BDV-infected primary rat hippocampal neurons. Molecular Medicine Reports. 10.3892/mmr.2016.5959.