许可

重庆医科大学附属第一医院神经内科医师。现担任中国医药教育协会神经免疫专业委员会 委员、重庆市医师协会神经免疫学组委员。

研究方向

主要研究领域为抑郁症发生过程中代谢物和蛋白质紊乱的病理生理机制及发掘有效临床诊断标志物。以第一作者/通讯作者在Journal of Advanced Research、SCIENCE CHINA Life Sciences、Translational Psychiatry (4篇)、Communications Biology、Journal of Affective Disorders等发表12篇SCI论文。主持国家自然科学基金1项、中国博士后科学基金特别资助1项、中国博士后科学基金面上项目1项、重庆市博士后特别资助项目1项、重庆市自然科学基金1项、重庆医科大学附属第一医院博士后资助项目1项；参与重庆医科大学未来医学青年创新团队1项。申请国家发明专利4项。

代表性论文

1. Xu K, Wang M, Wang H, Zhao S, Tu D, Gong X, Li W, Liu X, Zhong L, Chen J, Xie P. HMGB1/STAT3/p65 axis drives microglial activation and autophagy exert a crucial role in chronic Stress-Induced major depressive disorder. J Adv Res. 2024 May;59:79-96.

2. Xu K, Zhao S, Ren Y, Zhong Q, Feng J, Tu D, Wu W, Wang J, Chen J, Xie P. Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder. Transl Psychiatry. 2024 May 11;14(1):202.

3. Xu K, Ren Y, Zhao S, Feng J, Wu Q, Gong X, Chen J, Xie P. Oral D-ribose causes depressive-like behavior by altering glycerophospholipid metabolism via the gut-brain axis. Commun Biol. 2024 Jan 9;7(1):69.

4. Xu K, Ren Y, Fan L, Zhao S, Feng J, Zhong Q, Tu D, Wu W, Chen J, Xie P. TCF4 and RBFOX1 as peripheral biomarkers for the differential diagnosis and treatment of major depressive disorder. J Affect Disord. 2024 Jan 15;345:252-261.

5. Xu K, Zhou X, Ren Y, Zhao S, Feng J, Zhang H, Zhong Q, Wu W, Chen J, Xie P. IDH2/PPARγ pathway as a novel diagnostic biomarker panel for schizophrenia. Asian J Psychiatr. 2023 Nov;89:103788.

6. Xu K, Zheng P, Zhao S, Wang J, Feng J, Ren Y, Zhong Q, Zhang H, Chen X, Chen J, Xie P. LRFN5 and OLFM4 as novel potential biomarkers for major depressive disorder: a pilot study. Transl Psychiatry. 2023 Jun 6;13(1):188.

7. Xu K, Zheng P, Zhao S, Feng J, Pu J, Wang J, Zhao S, Wang H, Chen J, Xie P. Altered MANF and RYR2 concentrations associated with hypolipidemia in the serum of patients with schizophrenia. J Psychiatr Res. 2023 Jul;163:142-149.

8. Xu K, Zheng P, Zhao S, Wang M, Tu D, Wei Q, Feng J, Wang H, Chen J, Xie P. MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder. Transl Psychiatry. 2022 Dec 30;12(1):527.

9. Xu K, Wang M, Zhou W, Pu J, Wang H, Xie P. Chronic D-ribose and D-mannose overload induce depressive/anxiety-like behavior and spatial memory impairment in mice. Transl Psychiatry. 2021 Feb 2;11(1):90.

10. Xu K, He Y, Chen X, Tian Y, Cheng K, Zhang L, Wang Y, Yang D, Wang H, Wu Z, Li Y, Lan T, Dong Z, Xie P. Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice. J Neurochem. 2019 Jun;149(6):799-810.